Murillo was born and spent the first ten years of his life in La Paila, a small town in the Valle del Cauca Department of Colombia, and one of the country's largest producer's of sugarcane. His parents moved to London when he was 10 years old.He attended Cardinal Pole Catholic School in Hackney, returning in 2021 to exhibit there as part of his Frequencies project. His early life has influenced much of the artist’s later work, particularly the artist’s engagement with ideas of labour, globalisation, and material conditions.
In 2007, Murillo earned his BA (Hons) in Fine Art at University of Westminster. After graduating, he worked as a teacher in a secondary school. In 2012, Murillo graduated from the Royal College of Art in London, with an MA in Fine Art. Living in East London, he often worked as an installer for the neighbourhood’s small galleries.